Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

American Journal of Therapeutics: July/August 2021 – Volume 28 – Issue 4 – p e434-e460


Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.

Therapeutic Advances: 

Meta-analysis of 15 trials found that ivermectin reduced risk of death compared with no ivermectin (average risk ratio 0.38, 95% confidence interval 0.19–0.73; n = 2438; I2 = 49%; moderate-certainty evidence). This result was confirmed in a trial sequential analysis using the same DerSimonian–Laird method that underpinned the unadjusted analysis. This was also robust against a trial sequential analysis using the Biggerstaff–Tweedie method. Low-certainty evidence found that ivermectin prophylaxis reduced COVID-19 infection by an average 86% (95% confidence interval 79%–91%). Secondary outcomes provided less certain evidence. Low-certainty evidence suggested that there may be no benefit with ivermectin for “need for mechanical ventilation,” whereas effect estimates for “improvement” and “deterioration” clearly favored ivermectin use. Severe adverse events were rare among treatment trials and evidence of no difference was assessed as low certainty. Evidence on other secondary outcomes was very low certainty.


Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.


10 thoughts on “Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines”

  1. But we live in perpetually opposite day world hence our public health ‘leaders’ prefer expensive, not effective jabs with significant adverse affects. When will opposite day end and how will it end?

  2. Just heard a talk from Robert Malone (inventor of mRNA technology) who mentioned that he just recently took a three day course of ivermectin for long covid symptoms. He claims he feels better and sleeps better than he has in a long time.

  3. Lord Jesus, Have mercy on the disobedient clergy of Your Church who have refused for almost 100 years to consecrate Russia to the Immaculate Heart of Your sweet Mother!

    1. Big Earl, they cannot isolate the corona sars covid-19, but yet somehow perfect a potion to fight what they cannot see. I believe they used the influenza, which is now extinct as you know, as a base for the kill jab. The majic potion contains unspecified ingredients detrimental to the extinction of mankind. They know what it will do, and variants, ever so small will kill a lot of people.

      From this morning’s Psalm 52

      Unto the end, for Maeleth, understandings to David. The fool said in his heart: There is no God. [2] They are corrupted, and become abominable in iniquities: there is none that doth good. [3] God looked down from heaven on the children of men: to see if there were any that did understand, or did seek God. [4] All have gone aside, they are become unprofitable together, there is none that doth good, no not one. [5] Shall not all the workers of iniquity know, who eat up my people as they eat bread?

      They have not called upon God: there have they trembled for fear, where there was no fear. For God hath scattered the bones of them that please men: they have been confounded, because God hath despised them. [7] Who will give out of Sion the salvation of Israel? when God shall bring back the captivity of his people, Jacob shall rejoice, and Israel shall be glad.

    2. Welcome to the club, Big Earl, a small one here. Proud to be not complying, and over our dead bodies by the way, no juice. Our peace with God gives us great strength. By the way, these death vaxxed souls are becoming a nuisance here. Unbalanced! We must pray for them, and us.

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